Dissecting the Genetic Architecture of Lipids, Lipoproteins, and Apolipoproteins

Dissecting the genetic architecture of lipids, lipoproteins, and apolipoproteins: lessons from twin studies.

We review the ways in which twin studies have been used to investigate the genetic architecture of lipids, lipoproteins, and apolipoproteins. We focus on the age dependency of genetic effects and the importance of pleiotropy for the lipid system. Finally, consequences are discussed of age dependency and pleiotropy for the design and power of twin studies aimed at detecting the actual quantitati...

Serum lipids, lipoproteins and apolipoproteins in pregnant non-diabetic patients.

AIMS To investigate the effect of pregnancy on serum concentrations of lipids, lipoproteins, and apolipoproteins. METHODS Fasting serum concentrations of total cholesterol, triglyceride, low density lipoprotein cholesterol (LDL), high density lipoprotein cholesterol (HDL), apolipoproteins AI, AII, and B, and lipoprotein (a) were measured in 178 women with normal glucose tolerance in the secon...

Genetic and environmental influences on lipids, lipoproteins, and apolipoproteins: effects of menopause.

OBJECTIVE Levels of lipids and (apo)lipoproteins are known to increase after menopause, but it is unknown whether the genetic and environmental variability alters or whether lipids and (apo)lipoproteins are influenced by different genes before and after menopause. METHODS AND RESULTS We studied 453 monozygotic and 1280 dizygotic pairs of female white twins recruited from the St. Thomas' UK Ad...

Normal variation of plasma lipoproteins: postural effects on plasma concentrations of lipids, lipoproteins, and apolipoproteins.

We examined the effects of postural change on the concentrations of plasma cholesterol, triglyceride, high-density lipoprotein (HDL) cholesterol, apolipoproteins (apo) A-I and B, and lipoprotein(a) [Lp(a)] in six volunteers who fasted 12 h before blood sampling. Baseline samples were drawn in the standing position; the subjects then assumed the supine or sitting position, and additional blood s...

Lipoproteins and Apolipoproteins of the Ageing Eye